This is one of John Wesley's last letters. Wesley had been preaching in Leatherhead on February 18th, and then visited friends in Balham, London, on February 24th. This short letter was written on February 22nd, just before he went to Balham.
The letter was dictated, only the signature is John Wesley's, and Wesley did still "hope to be at Bristol next week". Two days later, on Feb. 24th, Wesley wrote his final letter to William Wilberforce about the "execrable villainy" of slavery, and the following day he started feeling ill. He passed away a few days later, on March 2nd, 1791, in his 88th year.
The name of the recipient of this letter is hard to make out (Mr Churdrey?), but it was sent to near Hay-on-Wye, Brecon.